Albizia used to treat allergic rhinitis, urticaria and asthma

CLINICAL USE
Albizia has not been significantly investigated under clinical trial conditions, so evidence is derived from tradition, in vitro and animal studies.

ALLERGY AND ASTHMA
Albizia is mainly used to treat allergic rhinitis, urticaria and asthma in clinical practice. In vitro and in vivo evidence of mast-cell stabilisation provide a theoretical basis for its use in allergic conditions; however, the clinical significance is unknown.

OTHER USES
Traditionally, a juice made from the leaves has been used internally to treat nightand seeds have been used to relieve diarrhoea, dysentery and Albizia 14 treat haemorrhoids, most likely because of their astringent activity

been used as an emollient to soothe eruptions, swellings, boils and carbuncles. In Ayurvedic medicine, it is used to treat bronchitis, asthma, allergy and inflammation.
DOSAGE RANGE
As clinical research is lacking, the following dosages come from Australian manufac- turer recommendations.
· Liquid extract (1:2): 3.5–8.5 mL/day or 25–60 mL/week. · Dried herb: 3–6 g/day.
TOXICITY
This is unknown; however, research with the methanolic fraction of Albizia extract has identified a median lethal dose of 150 mg/kg (Kasture et al 2000).
ADVERSE REACTIONS
Insufficient reliable information available.
SIGNIFICANT INTERACTIONS
Controlled studies are not available; therefore, interactions are based on evidence of activity and are largely theoretical and speculative. BARBITURATES
Additive effects are theoretically possible, as potentiation of pentobarbitone-induced sleep has been observed in vivo — use with caution.

ANTIHISTAMINES AND MAST-CELL-STABILISING DRUGS
Additive effects are theoretically possible because both in vitro and in vivo tests have identified significant mast-cell-stabilisation activity similar to that of cromoglycate — potentially beneficial interaction.

TRICYCLIC AND SELECTIVE SEROTONIN REUPTAKE INHIBITOR ANTIDEPRESSANT DRUGS
Increased risk of serotonin syndrome is theoretically possible, as Albizia increases serotonin levels, according to in vivo studies — observe patient.

CONTRAINDICATIONS AND PRECAUTIONS
Significant reductions in male fertility have been reported in tests using animal models; however, it is not known whether the effects also occur in humans. Until further research is conducted, caution is advised.

PREGNANCY USE
Insufficient reliable information available.